Pharmaceutical Drug Development (Small Molecules / Large Molecules)

small and large molecules
90% of current drugs are small molecules, but large molecules are quickly rising in popularity and importance.

In the world of pharmacology and drug development, there are two ways to classify the molecules used, as small and large molecules. This differentiation refers to more than size, it also helps classify how the molecules are made, their behavior, mode of action or transportation, and how suitable they are for different drug forms. More than 90% of current on-the-market drugs are small molecules, but large molecules, also known as biologics, are quickly rising in popularity and importance.

Small molecules have long been the basis for drug development. Their small size makes them easily ingestible in the gastrointestinal tract where active substances are immediately absorbed into the bloodstream and can travel anywhere in the body. The small size of these molecules allows them to easily penetrate cell membranes as they travel throughout the body.

Large molecules, or biologics, are classified as proteins having a therapeutic effect. In contrast to small molecule drugs, most large molecule drugs are complex and composed of more than 1,300 amino acids and are identical versions of human proteins. Large molecules work by transporting drugs to specific location within the body before releasing them before their destination. These types of drugs are developed through complex processes, often more than 1,000 steps are necessary, and are given through injection or infusion as they would be ineffective if taken orally. Large molecule products include vaccines, blood, blood components, gene therapy, tissue, and other proteins.

In recent years, biologics research has been at the forefront of drug development, offering treatment options for many medical conditions with no other options.

Small and large molecules test requests Contract Laboratory has helped facilitate

  • Pharma needs preclinical Contract Research Organization CRO for biological, small molecule (viral) in vivo studies of HBV and HCV infections
  • FDA GLP Bioanalytical Laboratory needed for GLP Small Molecule Study for Molecular Level Study and Extinction coefficient for a small molecule in MeOH and water
  • FDA GLP United States Bioanalytical laboratory needed for small molecule testing: Biopharmaceutical Classification System BCS Testing for GLP solubility and permeability tests for biowaivers for small molecules
  • Bioanalytical laboratory needed for biologics testing for residual simethicone from antifoam treatment in fermentation process for biological product for human use
  • Medical device company needs virology laboratory for virus testing of surgical products Biologics
  • FDA GMP Bioanalytical Laboratory needed for Biologics FDA GMP release testing of Licensed Biologics by RIA testing
  • to view these test requests and more like them, click here!

For help finding a preclinical Contract Research Organization  to perform your small molecule molecules pharmaceutical drug development research or testing, call us toll free at 1-855-377-6821 or submit a test request online!

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