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Toxicology Testing

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Toxicology testing for hazardous chemicals and public safety

The field of toxicology is a branch of science that “helps us understand the harmful effects that chemicals, substances, or situations, can have on people, animals, and the environment.” The field of toxicology has evolved from focusing on chemicals and poisons, to now being more about overall safety. Toxicology predicts how chemicals and other harmful substances may affect the public. The amount of exposure, the length of exposure, and a person’s age can all affect a person’s susceptibility to a potentially toxic sub.

There are more than 80,000 chemicals registered in the US with 2,000 new ones being introduced every year for use in everything from food and prescription drugs, to health and beauty products and cleaning products and unfortunately, the effects of most of these chemicals are often unknown. Toxicology aims to identify potential health hazards for those who come in contact with these chemicals, and safe levels of exposure.

Fortunately, there are a number of resources and databases for those interested in learning more about harmful chemicals and toxicology such as the IUPAC Glossary of Terms Used in Toxicology, the Hazardous Substance Data Bank (HSBD), LiverTox, and many more which can be seen on the U.S. Department of Health & Human Services Environmental Health & Toxicology website.

Contract Laboratory has helped facilitate numerous toxicology test requests like the following:

  • EPA environmental toxicology laboratory needed for acute toxicology testing/ EPA PRIA Action Code #A532 for antimicrobial pesticide registration of a product, which is an Oil/Water emulsion.
  • Product Safety Laboratory needed for Toxicology Testing to ISO 10903-5, SVHC Substances forbidden in EU Legislation Non-Cytotocic Latex free
  • Immedicatle need for clinical laboratory for Wellness panel blood, and urine toxicology for long term medicine use
  • Environmental toxicology laboratory needed for toxicological studies (acute , chronic and ecotoxicity ) for 2 insecticides including Certificate of analysis for impurities analysis for the two product Please specify costs for each product and the time which will take
  • FDA GLP Preclinical Pharmaceutical Contract Research Organization CRO needed for ICH and FDA GLP in-vivo toxicology study testing with the intravenous administration of pharmaceutical agent in canines
  • Large Industrial Bioscience Company needs pre-clinical contract research organization genotoxicology studies on substance including Ames and Chromosomal aberration studies.
  • View and respond to these test requests and more on our website.

If your organization needs a laboratory to perform toxicology testing on potentially hazardous chemicals or other substances, submit a test request on our website, or by calling us at 1-855-377-6821.

US National Toxicology Program’s Report on Cell Phone Safety

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Cell Phone safety testing

On May 27, 2016, the National Toxicology Program released a report outlining their findings on the potential health hazards of cell phones after a lengthy experiment conducted on mice and rats. The report in its entirety can be found here. The study looked mainly at radiofrequency radiation (RFR) and the negative affects it had on health.

Radiofrequency cell phone testing

Internal view of an open reverberation chamber that has two cage racks.

To complete the study, NTP routinely exposed the rodents to “frequencies and modulations currently used in cellular communications in the United States.” The rodents were exposed in 10 minute increments for a total of 9 hours a day from birth until age 2. Low incidences of tumors were found in the brains and hearts of male rats, but not female rats. The experiments are ongoing and complete results are expected by the end of 2017.

Steps that one can take to reduce radiofrequency exposure from cell phones include reducing the amount of time spent on a cell phone, using speaker mode or a headset to distance yourself from the phone, or acquiring a hands free kit.

Radiofrequency cell phone testing

External view of a row of reverberation chambers at the IIT Research Institute in Chicago, IL.

Contract Laboratory has received the following radiofrequncy and toxicology test requests:

  • Electronics Laboratory needed for light testing to pass FCC part 15 , Radiofrequency Devices and CA Prop 65 before selling those products.
  • India Lighting Manufacturer needs electrical laboratory for BIS radiofrequency disturbances test
  • EPA environmental toxicology laboratory needed for acute toxicology testing/ EPA PRIA Action Code #A532 for antimicrobial pesticide registration of a product, which is an Oil/Water emulsion.
  • GLP Environmental Toxicology laboratory needed for OECD testing of mammalian cell chromosome aberration in the presence of a chemical according to OECD Test No 473.
  • Cosmetics Toxicology laboratory needed for Phototoxicity studies and dermal testing of essential oils.
  • OECD GLP toxicology laboratory needed for Toxicology testing 5-BA physical-chemical properties on pesticides.
  • to view and respond to these test requests and more, visit our website.

If your organization is in need of a laboratory to perform radiofrequency, toxicology, or other testing, call us at 1-855-377-6821 or visit our website to submit a Toxicology Laboratory Test Request.

Radiofrequency cell phone testing

External view of a row of reverberation chambers at the IIT Research Institute in Chicago, IL.

European Chemicals Agency’s REACH Regulation

European Chemicals Agency REACH Regulation

European Chemicals Agency REACH Regulation

The European Union’s REACH regulation was adapted to determine the safety of chemicals and to improve the protection of human health and the environment from the risks that can be posed by chemicals. The REACH regulation also promotes alternative methods for the hazard assessment of chemicals.

The REACH regulations applies to all chemicals including industrial chemicals and substances used in day-to-day lives including chemicals used in cleaning products, paints, clothes, furnitureand electrical appliances. The REACH regulation is overseen by the European Chemicals Agency or ECHA.  Tp comply with the REACH regulations, companies must identify and manage the risks of the chemicals and demonstrate to ECHA how the chemicals can be safely used. ECHA than evaluates the chemical registration dossiers and the chemical testing proposals  to determine whether the chemical constitutes a risk to human health or the environment.

ECHA Evaluation focuses on three different areas:

  • Examination of testing proposals submitted by registrants
  • Compliance check of the dossiers submitted by registrants
  • Substance evaluation

 Contract Laboratory has helped many companies with their REACH Testing including the following projects:

  • Italian cosmetic company needs consumer product safety laboratory for REACH compliance testing and toxicological tests for REACH registration, 1-10 tons of materials

 

  • Company developing new line of towels needs consumer products laboratory for laundering test study: AATCC 96 testing (Dimensional Stability to Commercial Laundry). to show they can withstand frequent high-temp commercial laundry conditions at our customers’ large yoga studios. I need to reach below temperatures:wash = 170F (at least)dry = 190F (at least)

 

  • EPA GLP Toxicology Laboratory needed for GLP Toxicity Study to for REACH dossier

 

  • Toxicology Laboratory needed for REACH OECD polymer testing to OECD TG 118 (1996) method on phenolic syntans, melamine, dicyandiamide, naphthalene, chrome syntan and tanning auxiliaries used for leather industry OECD TG 118 (1996) method is written on ECHA ?Guidance for polymers &monomers? booklet for GPC analysis. We are searching laboratory which have certification for OECD TG 118 test.

 

  • Analytical Chemistry Laboratory needed for chemical analysis to determine composition of butyl reclaimed rubber to be able to assess the registration requirements of the EU REACH Regulation.

 

  • FDA Food Laboratory needed for medium density polypropylene sheets testing to REACH, ROHS, and FDA foodcontact standards

 

  • Asia Toxicology Laboratory enviromental toxicology testing for CLP and REACH classification of hazardous materials to Chemical, Labeling and Packaging (CLP) for EU REACH for hazards to GHS requirements for EU Safety Data Sheets

 

  • Jewelery manufacturer & exporter needs REACH testing on glass. Please include tentative costing that may be incurred in this test and approximate time taken to undergo this test & get the results.

 

  • Men’s dress shoe manufacturer needs laboratory for REACH testing and CPSIA testing. Materials are leather, EVA et TR.

 

  • Detergent Manufacturer needs product safety toxicology laboratory for OECD tests: Skin irritation OECD439 Skin corrosion (human skin model test) OECD431 Eye irritation / corrosion OECD405 or Bovine corneal opacity and permeability OECD 437 Our concern is that we certain mixtures of detergents to eliminate corrosivity, based on the calculation method of the mixture classification according to CLP. Mixtures, which according to the original classification REACH based only irritating, often based eye corrosive, in this case, the packaging symbol for corrosivity. Such labeling can be excluded if tests for eye corrosivity excluded. The test must be performed within the SLP. Then I would like to ask about tests that relate to the physical characteristics? E.g. determine the flash point, etc.

 

  • Asia or Europe OECD, GLP Laboratory needed for REACH Registration Testing: Pysicochemical and Toxicological testing for REACH Registration (EU Regulation for Chemicals)registration of the substance: ? IUPAC Name: (butylamine)[[2,2′-thiobis[4-(1,1,3,3-tetramethylbutyl)phenolato]](2-)-O,O’,S]nickel ? CAS: 14516-71-3 ? EC: 238-523-3 ? The substance is solid. We would like to send us an offer covering all the endpoints of IUCLID (testing and/or bibliographic research and/or QSAR including). GLP certificate necessary for the project. 1.4 Analytical information (substance identification) 4.10 Surface tension 4.11 Flash point Not applicable as solid 4.12 Auto flammability Waiving is possible depends from the melting point 4.13 Flammability 4.14 Explosiveness Waiving is possible 4.15 Oxidising properties Waiving is possible 4.17 Stability in organic solvents and identity of relevant degradation products 4.2 Melting point/freezing point 4.21 Dissociation constant. 4.22 Viscosity Not applicable for solids 4.3 Boiling point Waiving is possible depends from the melting point 4.4 Density 4.5 Particle size distribution (Granulometry) 4.6 Vapour pressure Waiving is possible 4.7 Partition coefficient 4.8 Water solubility 5.1.2 Hydrolysis Waiving is possible considering the use of the substance 5.1.3 Phototransformation in water Waiving is possible considering the use of the substance 5.2.2 Biodegradation in water and sediment: simulation tests Waiving is possible considering the use of the substance 5.2.3 Biodegradation in soil Waiving is possible considering the use of the substance 5.3.1 Bioaccumulation: aquatic / sediment Waiving is possible considering the use of the substance 5.4.1 Adsorption / desorption Waiving is possible considering the use of the substance 5.4.1 Adsorption/desorption screening study (HPLC method) Waiving is possible considering the use of the substance 5.6 Additional information on environmental fate and behaviour Waiving is possible considering the use of the substance 6.1 Aquatic toxicity Waiving is possible considering the use of the substance 6.1.2 Long-term toxicity to fish Waiving is possible considering the use of the substance 6.1.3 Short-term toxicity to aquatic invertebrates Waiving is possible considering the use of the substance 6.1.4 Long-term toxicity to aquatic invertebrates Waiving is possible considering the use of the substance 6.1.5 Toxicity to aquatic algae and cyanobacteria Waiving is possible considering the use of the substance 6.1.7 Toxicity to microorganisms Waiving is possible considering the use of the substance 6.2 Sediment toxicity Waiving is possible considering the use of the substance 6.3 Terrestrial toxicity Waiving is possible considering the use of the substance 6.3.1 Toxicity to soil macroorganisms except arthropods Waiving is possible considering the use of the substance 6.3.2 Toxicity to terrestrial arthropods Waiving is possible considering the use of the substance 6.3.3 Toxicity to terrestrial plants Waiving is possible considering the use of the substance 6.3.4 Toxicity to soil microorganisms Waiving is possible considering the use of the substance 7 Toxicological information 7.2.1 Acute toxicity: oral 7.2.2 Acute toxicity: inhalation 7.3.2 Eye irritation 7.5.1 Repeated dose toxicity: oral 7.5.2 Repeated dose toxicity: dermal 7.5.3 Repeated dose toxicity: inhalation 7.8.1 Toxicity to reproduction

 

  • United States polymer laboratory needed for REACH compliance testing: project that has been approved that will use our reprocessed Copolymer Polypropylene black pellets. In order to move forward with this project, our customer is requiring us to provide them with a REACH compliance letter along with test data. I am in search of a company that will be able to provide this information for us.

 

  • European Union Electrical Laboratory needed for RoHS testing and REACH Compliance testing: Could you perform analysis for substance detection as (reference: current list of SVHC published by the ECHA) on smart-cards (SIM)? RoHS: Could you do also analysis of the same article for confirming the RoHS compliance? If yes, what’s the lead-time and fare?

 

  • GLP Toxicology Laboratory needed for GLP REACH Toxicology Studies of one chemical substance: Two-generation reproduction toxicity study, EU B.35/OECD 416 Repeated dose (28 days) toxicity (inhalation), EU B.8/OECD 412 please specify price for DRF, analytics, limit and full study
  • Materials Laboratory REACH testing of PSA masking films.
  • Large Toy Manufacturer needs Toxicology Laboratory for Toy Testing: Toxicology Testing Toxicological Risk Assessment (TRA) Based on the ingredients or bill of substances to evaluate or assess any hazardous substances involved on the materials. The requirement should be referenced to EU REACH,SVHC,2009/48/EC, Washington Children’s Safe Product Act or California Green Chemistry Act, etc.

VIEW MORE REACH REGULATION TEST REQUESTS

Are you a toxicology laboratory that performs REACH regulation Testing. If so, visit more of our many more projects which can be seen at Incoming REACH Test Requests

NEED REACH REGULATION TESTING?

Are you a manufacturer that is exporting to, distributing, selling or manufacturing in the European Union? If so, you will want to make sure your exporter, distributor, store or manufacturer is in compliance with ECHA’s REACH regulation. So, call us at 1-855-377-6821 or Submit REACH Test Requests.

Scientist Review of Laboratory Test Requests

approved-1049259__340Did you know Contract Laboratory has Scientist Review and approval of every Laboratory Test Request that  we receive to ensure validity and accuracy? Each Laboratory Test Request is reviewed and approved by our PhD scientists to get more information regarding the testing needed and about the company or organization needing the testing.
Contract Laboratory receives many Laboratory Test Requests every day and all receive a only accepts those that can be validated and are legitimate so you can focus on what’s important – building relationships with your clients and increasing your testing services! Only once a Scientist Approval is performed is a Laboratory Test Request approved.
If you have any questions on oust Scientist Review of Laboratory Test Requests please contact our Laboratory Business Development Team at 1-855-377-6821

What is DNA purification?

DNA purification is an important step in studying genomics, molecular biology, and other clinical research. It is helpful in extracting enough genomic or plasmid DNA and purifying the DNA to reduce contaminants that could potentially compromise the research.medicine-163707__340

If DNA is contaminated, it is likely to cause errors in testing. By purifying a DNA sample it reduces the chance that errors will occur and better ensures the quality and purity of your sample.

DNA purification can be done through different processes such as mechanical disruption, chemical treatment or enzymatic digestion.

Contract Laboratory has received the following test requests regarding DNA purification:

  •  Genetics Laboratory neded for bacterial culturing and plasmid DNA purification. 160kB plasmid from one e.coli strain to another via electroporation. We would like to provide the donor and acceptor e.coli strains and have lab handle the following steps: 160KB BAC DNA purification (e.g. culture 600mL of bacteria before miniprep) make the acceptor coli electro-competent transfect the acceptor bacteria using electroporation
  • Food technology company needs Genetics Laboratory for DNA purification and QPCR analysis testing: Samples to be tested against 10 different primer/probe sets.
  • EU FDA GLP genetics and genomics laboratory needed for DNA purification from PAXGene tubes
  • These test requests and more can be seen here

If your organization or company is in need of a laboratory to perform DNA purification or other DNA testing, submit a DNA test request online or by calling 1-855-377-6821.

Winter Wonderland

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This winter has been unusually snowy here in Idaho at Contract Laboratory headquarters. But it hasn’t stopped us from enjoying the beauty of mother nature around us! These winter wonderland photos were taken by one of our employees on a winter hike.20161225_133741-03_1482938851556a

We hope they inspire you to get out and explore and enjoy the new year as much as they have us!

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We’d love to see some of the snow, sunshine, or winter beauty near you! Share your photos with us via Twitter @ContractLab or on Facebook @contractlaboratory

 

2017 Resolutions

Happy New Year!

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2017 is here and it is off with a bang! We at Contract Laboratory have been hard at work preparing for a busy new year, but we’ve also taken some time to get outside and enjoy mother nature. Our employees here at Contract Laboratory enjoy being outside and have resolved to spend more time in the great outdoors. Some are already making good on their resolutions, take a look at their pictures from a winter hike to Tamanawas Falls near Mt Hood, Oregon!

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Does your laboratory have resolutions for 2017? Or maybe you have a great personal resolution you don’t mind sharing, let us know! Tweet us your resolutions @ContractLab or on Facebook @contractlaboratory!

Wishing you all a safe and happy 2017!

London Holiday Christmas Lights

Thank you, Trinity Scientific!

Thank you Trinity Science for sending us photos of the beautiful Christmas lights in London. United Kingdom Science at work

If you are a laboratory, send us photos of the holiday lights in and around your laboratory for us to share for New Years! Email them to admin@contractlaboratory.com Enjoy and Happy New Years from all of us at ContractLaboratory.com – The Laboratory Outsourcing Network!

 

United Kingdom CHristmas Lights

United Kingdom Christmas Lights

London Holiday Christmas Lights 2016

London Holiday Christmas Lights 2016

United Kingdom Christmas Lights

United Kingdom Christmas Lights

Hepatotoxicity

Hepatotoxicity is a termclose-up-1853400__340 used to describe damage to the liver caused by a medicine, chemical, or dietary supplement, or it can also be a side effect of HIV drugs. The liver’s role in the body is to filter substances, such as medicines, from the blood. Liver damage occurs when the liver is bombarded with more toxins than it can deal with and ultimately cause the liver to under function.

Signs of liver damage include stomach pain , tiredness, nausea, jaundice, dark urine, and fever. Liver damage, hepatotoxicity, is diagnosed through many different types of tests including blood tests such as billirubin or liver enzymes, a liver biopsy, CT scans, and more.

Some 900 drugs have been determined to cause liver injury. There is no cure or treatment for liver damage, and management of hepatotoxicity varies depending no the amount of damage and the cause. In most cases, the drug thought to be causing the damage is discontinued, drugs to reduce symptoms may also be prescribed.

If you already have liver damage, alcohol, actaminophen, drugs to treat high cholesterol, and any medication that has previously caused liver issues, should be avoided as they are known to exacerbate the problem.

If you are an organization that needs a laboratory to perform hepatotoxicity testing or scientific research, call us at 1-855-377-6821, or submit a test request on our website.

 

CPSC Toy Safety Testing

CPSC Toy Safety Testing

CPSC Toy Safety Testing

With kids getting ready to unwrap lots of toys this holiday season, we thought we would highlight the importance of CPSC Toy Safety Testing and thank the US Consumer Product Safety Commission and US Customs and Border Patrol for making our children’s toys safer! A new report issued in November, 2017 by the CPSC highlights how the CPSC and U.S. Customs and Border Protection (CBP) are collaborating to keep unsafe toys off the shelves.

during the past four years, 8 million units of about 4,500 different types of toys were stopped  due to safety hazards or the failure to meet federal safety standards

 

From classic toys like legos and wooden blocks to high technology computerized remote controlled cars,  CPSC Toy Safety Testing ensures the safety of toys solc in the US. With Christmas and the Holiday Season upon us, we are reminded of the importance of CPSC Toy Safety Testing.  Since 2012, the U.S. Consumer Product Safety Commission (CPSC) and the U.S. Customs and Border Protection (CBP), have kept more than 4,500 toys and children’s products out of the U.S. due to safety standard violations such as small parts, lead, and even labeling requirements. Inspection of cargo at ports by both agencies has helped identify and detain these unsafe toys. In an effort to avoid toys and products being detained, the CPSC enforces safety standards and even trains manufacturers regarding safety standards.

In 2015, there were about 185,500 toy related injuries in children under 15, mainly involving cuts or bruises to the face, however there was also a reported 11 deaths. But toy recalls alone have declined from 172 in 2008, to just 24 in 2016. Most toys are recalled for choking hazards, high levels of lead, mechanical hazards, and fire hazards.  CPSC Toy Safety Testing by independent, third-party toy laboratories can ensure the safety of toys from choking hazards, high levels of lead, mechanical hazards and fire hazards.

Contract Laboratory helps toy makers and toy manufacturers with the outsourcing of their CPSC Toy Safety Testing. The following are examples of projects from toy makers and toy manufacturers >

  • Large Toy manufacturer needs Textile laboratory for denier counts and construction confirmation testing for three tricot fabric cuts.
  • Consumer Products Laboratory needed for ISO 8124 or EN71 testing of soft play book for children 3+ to ISO8124, Safety of Toys or EN71.
  • Consumer Products Safety Laboratory needed for product testing and certification for a children’s toy/furniture product children’s step/stool made of wood.
  • Company selecting textile products ( toy like) that require testing for the Canadian market There are 2 textile products that appeal to be used by children under 3 years old Also an infant textile bib with velcro. Testing includes Textile Flammability Regulations (SOR/2011-22) No flame retardant PBB Prohibition of Certain Toxic Substances Regulations, 2012 (SOR/2012-285) Toys Regulations (SOR/2011-17)
  • Analytical Chemistry Laboratory needed for benzene testing of toys to potentially develop program going forward
  • Toxicology laboratory needed for GLP toxicity testing such as acute oral toxicity test for new plastic polypropylene baby toys.
  • Los Angeles area materials laboratory needed for ASTM Testing of toy building kits

ARE YOU A CONSUMER PRODUCTS OR TOY LABORATORY?

View more incoming  CPSC Toy Safety Test Requests

DO YOU NEED A TOY LABORATORY

Whether you manufacture or distribute dolls, games, puzzles, electronic play robots or scooters, Contract Laboratory can help you with the outsourcing of your CPSC Toy Safety Testing.  If your company is a toy maker or toy manufacturer, ensure the safety of your toys  by finding a laboratory to perform your CPSC toy safety testing, by calling us at 1-855-377-6821 or submit a Toy Safety Test Request online.

Read the full US Consumer Product Safety Commission News Report  at https://www.cpsc.gov/Newsroom/News-Releases/2017/Safer-Together-CPSC-and-CBP-Collaborate-to-Keep-Unsafe-Toys-Off-Store-Shelves


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