Ovarian Cancer Early Detection Tests Development

Ovarian Cancer Early Detection Tests Development

Ovarian cancer research
About 20% of ovarian cancers are found at early stages yet when found early, 94% of patients live more than 5 years after their diagnosis.

Early detection of cancer is important in the treatment of disease. A blood test created by the Georgia Institute of Technology detects ovarian cancer with 90 percent accuracy. To read the article, visit here. According to the American Cancer Society, only about 20% of ovarian cancers are found at early stages yet when it is found early, 94% of patients live more than 5 years after their diagnosis.

Ovarian cancer is the 5th leading cause of death for women in the US and is often difficult to detect in early stages because many women are asymptomatic. In the test developed by the Georgia Institute of Technology, researchers studied blood serum compounds with differing molecular weights in order to establish a biomarker which is an effective tool to use in early-stage ovarian cancer screenings. Early-stage detection is essential as the survival rate is almost 90 percent when the disease is detected early.

Using a combination of techniques including liquid chromatography, mass spectrometry, and algorithms, the researchers were able to identify a number of women with early-stage ovarian cancer. These techniques also helped researchers identify 16 metabolite compounds used to differentiate between women with and without early-stage ovarian cancer with high accuracy. The study is a good indicator that combining algorithms with analytical chemistry techniques shows promise for diagnostic testing.

Previously, ovarian cancer was detected during a regular women’s health exam where a healthcare professional would feel the ovaries to determine size and shape, however tumors on the ovaries are extremely difficult to feel. Transvaginal ultrasounds which use sound waves to look at the reproductive organs were another commonly used method of ovarian cancer screening, though this method could detect masses, it couldn’t determine whether or not they were cancerous.

Contract Laboratory has helped many organizations find laboratories to perform, their cancer research or studies, such as the following:

  • Preclinical laboratory needed for method development of an immunofluorescence method to be used for nuclear beta catenin and applied to preclinical studies with human cancer tissue and to clinical trial specimens. Due to nature of drug action, method must be specific for detection of nuclear, and not cytosolic, beta catenin. Method will require confocal microscope. We have the antibody for nuclear beta catenin available commercially.
  • Oncology Preclinical Contract Research Organizations CRO needed for in vivo studies of primary or metastatic hepatic / liver cancer using VX2 rabbit and/or Walker 256 rat/mouse orthotopic models. CRO must allow drug payload to be delivered by an external magnetic set up, steered by an MD/bioengineering member of our team.
  • Bioanalytical laboratory needed for microarray testing of RNA samples extracted from urinary bladder cancer tissues.
  • Bioanalytical laboratory needed for microarray testing of RNA samples extracted from urinary bladder cancer tissues.
  • Pharmaceutical Contract Research Organization needed for oncology preclinical study of a therapeutic nanoparticle drug delivery systemin Breast cancer mice (HER2 positive)
  • Germany or Europe Contract Research Organization needed for preclinical study to Test of novel immune stimulatory compounds in a mouse cancer model. Compounds are provided, mouse lab needed.
  • Bioanalytical Laboratory needed for polarimetry testing of bioactive isolate compound isolated the bioactive compound purified to novel drug which has cytotoxic activity against several cancer cell lines. We now are looking for the test service who could perform a polarimetry test over our compound to proceed with further publication.
  • More test requests can be seen here!

If your organization is in need of a laboratory to help perform your cancer research or testing, we can help! Learn more by calling us at 1-855-377-6821 or visit us online!